Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation
Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins—such as ISG15, FAT10, Nedd8, SUMO, and Atg3—share a common structural fold. However, their respective activating enzymes, collectively termed E1, exhibit notable differentiation. For instance, UBA1, UBA6, …